If you’re craving something cozy, creamy, and downright irresistible, you’re going to want to try this Chicken Alfredo Lasagna Recipe. It’s like the best of both worlds—the rich, velvety Alfredo sauce layered with tender chicken, spinach, and plenty of melty cheese all wrapped up in delicate lasagna sheets. I absolutely love how this turns out every single time, and I promise once you make it, it’ll become a go-to in your dinner rotation.

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Why You’ll Love This Recipe

Creamy, cheesy layers: The alfredo sauce is silky smooth, giving every bite that luxurious feel.
Balanced flavors: Tender chicken and fresh spinach add heartiness without overwhelming the dish.
Family-friendly: Everyone from picky eaters to comfort food lovers will go crazy for this.
Make-ahead friendly: Prep it early and bake when ready, perfect for busy weeknights or entertaining.

The image shows a white baking dish filled with a lasagna that has four visible layers. The top layer is golden brown, bubbly melted cheese with some darker brown spots and a few green basil leaves scattered on top. Underneath is a thick white sauce layer dotted with fresh spinach leaves adding green color. Below, there is a creamy chicken and cheese mixture layer with a soft, smooth texture, and at the bottom, a slightly browned sauce-covered pasta layer is visible. A golden spatula is lifting one piece, showing the layers clearly and the melted cheese stretching slightly. The dish is placed on a white marbled surface. Photo taken with an iphone --ar 4:5 --v 7

Ingredients You’ll Need

Every ingredient in this Chicken Alfredo Lasagna Recipe has a job to do—whether it’s building that creamy sauce or adding texture and flavor. I find using fresh spinach and quality cheeses really elevates the whole dish, so don’t skimp on those!

Olive oil: Helps sauté the spinach quickly without overpowering flavors.
Spinach: I like fresh for texture and color, but frozen works too if pressed well.
Butter: The base of the alfredo sauce, giving it richness.
All-purpose flour: Creates the roux that thickens the sauce perfectly.
Whole milk: I find whole milk adds a creamy consistency that’s just right.
Ground nutmeg: Just a pinch enhances the sauce’s flavor—don’t skip it!
Salt and pepper: Enhances every layer; adjust to your taste.
Parmesan cheese: Adds that signature sharpness and depth to the alfredo sauce.
Ricotta cheese: Keeps the layers moist and adds a dreamy texture.
Lasagna sheets: Either no-boil or regular—just be sure to adjust cooking time accordingly.
Cooked chicken: I usually use rotisserie for ease and flavor, shredded for even layering.
Mozzarella cheese: The gooey, melty topping that everyone loves.

Note: You’ll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Variations

I love making this Chicken Alfredo Lasagna Recipe my own by switching up a few ingredients depending on what’s in the fridge or who I’m cooking for. Feel free to get creative—you’ll be surprised how versatile this recipe is.

Vegetarian Version: Skip the chicken and add mushrooms or artichokes—I always keep veggies handy for this swap.
Spicy Kick: Add a pinch of red pepper flakes into the alfredo sauce; I did this once and it was a game changer!
Gluten-Free: Use gluten-free lasagna noodles and ensure your flour substitute works for thickening the sauce.
Extra Greens: Toss in kale or swiss chard with the spinach for a nutrient boost; just make sure to cook them down well.

How to Make Chicken Alfredo Lasagna Recipe

Step 1: Wilt the Spinach

Start by heating a tablespoon of olive oil in a skillet over medium heat. Add the fresh spinach and cook it just until it wilts—about 2 minutes—you want it tender but still vibrant. Drain any excess moisture and set it aside. This step keeps your lasagna from getting soggy later on.

Step 2: Make the Alfredo Sauce

In a large saucepan, melt the butter over medium heat, then whisk in the flour to make a roux. Cook this for 1-2 minutes while whisking, so it loses that raw flour taste but doesn’t brown. Slowly add the milk while whisking constantly to avoid lumps. Keep stirring as the sauce simmers—it should thicken enough to coat the back of a spoon in 5-7 minutes. Remove from heat and stir in parmesan cheese, a pinch of nutmeg, and salt and pepper. The sauce is your secret weapon here—rich and creamy but perfectly balanced.

Step 3: Prepare the Ricotta Layer

Season your ricotta cheese with a little salt and pepper—it’s simple but adds so much flavor when it melds with the other layers. I like to stir it gently just to combine; you don’t want to make it watery.

Step 4: Assemble the Lasagna

Grab your baking dish and start spreading a thin layer of Alfredo sauce on the bottom to prevent sticking. Lay down your first layer of lasagna sheets—make sure they cover the sauce without overlapping too much. Next, spread a third of the ricotta cheese evenly across the pasta, then sprinkle a third of your shredded chicken and wilted spinach. Top it with a third of the mozzarella and drizzle some Alfredo sauce over everything. Repeat this layering two more times until you run out of ingredients, finishing with a good layer of mozzarella and Alfredo sauce on top. Cover the dish tightly with foil to keep it moist as it bakes.

Step 5: Bake to Perfection

Bake covered at 375°F (190°C) for 20 minutes, then remove the foil and bake another 10 minutes until the cheese is golden and bubbly. This final uncovered bake is what gives you that gorgeous, melty top we all love. Let the lasagna rest for at least 15 minutes—this makes slicing easier and lets all those flavors settle beautifully.

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Pro Tips for Making Chicken Alfredo Lasagna Recipe

Don’t rush the sauce: Stir continuously to prevent lumps and burning—I learned this after my first patchy sauce disaster.
Use rotisserie chicken: It saves so much time and adds fantastic flavor, plus your shredded chicken stays juicy.
Drain spinach well: Too much moisture can make your lasagna watery; I like to press it in a sieve or towel.
Let it rest: I used to skip this—big mistake! Resting locks in the layers and ensures clean slices.

How to Serve Chicken Alfredo Lasagna Recipe

A piece of lasagna with three visible layers sits on a white plate with a delicate pattern. The bottom layer is creamy white sauce mixed with green spinach, the middle layer shows a light yellow pasta sheet, and the top layer is golden brown melted cheese with a few small fresh green basil leaves on top. The lasagna looks soft and slightly browned in some spots. Black pepper is sprinkled around on the plate, and a silver fork is placed resting near the lasagna. The surface underneath is a white marbled texture. photo taken with an iphone --ar 4:5 --v 7

Garnishes

I like to sprinkle freshly chopped parsley or basil on top for a pop of color and freshness right before serving. A little cracked black pepper on each plate adds a nice final touch, too. Sometimes a grating of extra parmesan cheese doesn’t hurt, especially if you’re serving family who loves an extra cheesy bite.

Side Dishes

This lasagna is rich, so I usually pair it with a crisp green salad dressed in lemon vinaigrette or steamed green beans for a simple, fresh contrast. Garlic bread is a classic side that my family can’t resist, especially for soaking up any leftover sauce on the plate.

Creative Ways to Present

For special occasions, I’ve layered this in smaller individual ramekins for personal lasagnas—it’s a fun way to serve guests and looks really elegant. Another fun idea is to add edible flower petals or microgreens on top for a restaurant-style presentation that impresses without extra fuss.

Make Ahead and Storage

Storing Leftovers

I usually store leftover Chicken Alfredo Lasagna in an airtight container in the fridge for up to 4 days. Make sure it cools completely before covering to avoid condensation making the top soggy. Leftovers taste great warm or even cold if that’s your thing!

Freezing

This recipe freezes beautifully—just assemble the entire lasagna, cover tightly with foil and plastic wrap, then freeze for up to 3 months. When you’re ready, thaw it in the fridge overnight and bake as usual, adding a little extra cooking time if it’s still cold inside.

Reheating

Reheat leftovers in the oven at 350°F (175°C) covered with foil to keep moisture in, for about 20 minutes or until warmed through. I try to avoid microwaving because it can make the lasagna a bit rubbery, but if you’re short on time, microwave in short bursts with a cover to keep it moist.

FAQs

Can I use no-boil lasagna noodles for this Chicken Alfredo Lasagna Recipe?

Yes! No-boil noodles work well here and save you a step. Just make sure your sauce is a bit more liquidy to help the noodles cook properly while baking. You might want to add a few extra minutes to your baking time as well.
Is it better to use fresh or frozen spinach?

Fresh spinach is my favorite for this recipe because it gives a nice texture and bright color, but frozen spinach can work in a pinch. Just be sure to thaw and squeeze out as much water as possible to prevent your lasagna from getting watery.
How can I make this recipe vegetarian?

Simply omit the chicken and replace it with sautéed mushrooms, roasted vegetables, or even a blend of cheeses. You can also add extra spinach or kale to keep it hearty and filling.
Can I prepare this Chicken Alfredo Lasagna Recipe ahead of time?

Absolutely! You can assemble the whole lasagna the day before, cover it tightly, and refrigerate. When you’re ready, bake it straight from the fridge, just add about 10 extra minutes to the baking time.
What’s the best way to prevent the lasagna from drying out?

Covering the lasagna with foil during the majority of the baking time traps moisture and keeps the noodles tender. Also, don’t forget that resting period after baking, which helps the sauce settle and keeps everything moist.

Final Thoughts

This Chicken Alfredo Lasagna Recipe holds a special spot on my weeknight dinner list because it’s comforting and impressive without being complicated. Whenever I make it, my family lights up at the table, and leftovers are fought over the next day! If you want something that feels fancy but comes together easily, give this one a try—I’m confident you’ll be adding it to your favorites too.